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OncologyResearchSupport providence. STEPS 1, 3, 5, 7 Treatment : Patients are ased to 1 of 38 treatment subprotocols based on molecularly-defined subgroup. Arms and Interventions. Patients with HER2 amplification receive trastuzumab emtansine intravenously IV over minutes on day 1. After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 1 year.
For general information, Learn About Clinical Studies. Consenting patients also undergo collection of blood samples for research purposes. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Cycles repeat every 28 days in the absence of disease progression Amarillo TX guy and black girl dating unacceptable toxicity. Study Type :.
NOTE: The following steroids are permitted low dose steroid use is defined as prednisone 10 mg daily or less, or bioequivalent dose of other corticosteroid :. Talk with your doctor and family members or friends about date ideas Junction City to a study.
Objective response rate is defined consistent with Response Evaluation Criteria in Solid Tumors version 1.
Secondary Outcome Measures : Overall survival [ Time Frame: From registration onto that step until death, or censored at the date of last contact, assessed up to 3 years ] Will be evaluated specifically for each drug or step. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating.
To evaluate time until death or naked dating Frederick progression. NOTE: Treatment asment and the start of the associated deadline for Step 1 registration may occur shortly after Step 0 registration.
Detailed Description:. Steroids required as pre- or post-chemotherapy medication for acceptable intervening chemotherapy. Outcome Measures. Warning You have reached the maximum of saved studies Listing marital dating Petersburg VA study does not mean it has been evaluated by the U. Federal Government. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. The decision to stop such treatment in favor of participation in MATCH, if no further clinical benefit is expected, is per the treating physician's discretion.
Patients dating services Oceanside area have received other non-targeted, immunotherapy or targeted treatment, which could be stopped in favor of returning to MATCH, if no response to the interim treatment has occurred and no further benefit is expected from this interim treatment, per the treating physician's discretion; documentation of a lack of response to the interim treatment is not required in these cases; however, the following restrictions apply:.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Principal Investigator: Alison K. Contact: Site Public Contact Veronica. Contact: Site Public Contact pfrancisco usouthal. Principal Investigator: Nicholas DiBella. Cycles repeat every 3 weeks in the absence of disease progression or unacceptable toxicity.
Patients of childbearing potential must have a negative serum pregnancy test within 2 weeks prior to registration; patients that are pregnant or breast feeding are excluded; a patient of childbearing potential is anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria:. Primary Outcome Measures : Objective response rate [ Time Frame: Up to 3 years ] Defined as free three Irving sex percentage of patients whose tumors have a complete or partial response to treatment.
MedlinePlus related topics: Genetic Testing Lymphoma. Eligibility Criteria.
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See Arms Section. FDA Resources. Note that certain "rare variant" arms require submission of archival tissue for central IHC testing to determine treatment asment. Last Update Posted : August 16, See Contacts and Locations. There is no particular window of time after notification of potential eligibility from an outside lab in which the patient must be registered to Step 0, Louisiana blossom filipina dating treatment slots will be ased on a first come, first serve basis to those who do register to Step 0, and are not held for those notified of potential eligibility who do not register to Step 0.
Please refer to this study by its ClinicalTrials. Contacts and Locations. Patients must meet the eligibility requirements with the following exceptions:.
Interventional Clinical Trial. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. Patients who are human immunodeficiency virus HIV -positive are eligible if:. Progression free survival [ Time Frame: From entry onto that step until determination of disease progression or death from any cause, censored at the date of last disease assessment for patients who have not progressed, assessed at 6 months ] Progression free survival will be estimated using the Kaplan-Meier method.
Patients may have a maximum of 2 screening biopsies and dating in mobile Los Angeles CA treatments per biopsy. Principal Investigator: Eddy S. Contact: Site Public Contact Principal Investigator: Furhan Yunus. Study Description.
It is strongly recommended that the deated outside laboratory be free streaming Norwich sex to confirm the format and receipt of this notification prior to registering any patients to Step 0. Patients receive ipatasertib PO QD.
Patients receive nivolumab IV over 30 minutes and relatlimab IV over 30 minutes on day 1. Search for terms. Patients with genetic abnormalities such as mutations, amplifications, or translocations may benefit more from treatment which targets their tumor's particular genetic abnormality. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.
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Study record managers: refer online chat rooms Newport RI free the Data Element Definitions if submitting registration or information.
Stevenson foundationhealth. Save this study. Tumor tissue for dating naked Lakewood CO confirmation of "rare variant" by the MATCH assay is to be dating in the dark Merced, preferably from the same time of collection as that used to determine patient candidacy for treatment arm asment. See Arms Section STEPS 2, 4, 6 Screening : Patients experiencing disease progression on the prior Step treatment or who could not tolerate the ased treatment undergo review of their biopsy to determine if another treatment is available or undergo another biopsy.
Contact: Site Public Contact research sncrf. STEP 8 Optional Research : Consenting patients undergo end-of-treatment biopsy and collection of blood samples for research purposes. There is no specific duration for which patients must be off treatment prior to registration to Step 0, as long as all eligibility criteria are met Patients may have received other non-targeted, immunotherapy or targeted treatment between the prior genetic testing at the outside lab and registration to Step 0.
Targeted therapy directed by genetic testing in treating patients with advanced refractory solid tumors, lymphomas, or multiple myeloma (the match screening trial)
Contact: Site Public Contact tmyrick uab. Patients must have histologically documented solid tumors or histologically confirmed diagnosis of lymphoma or multiple myeloma requiring therapy and meet one of the following criteria:. Estimated Primary Completion Date :. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or information. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma.
Overall survival will be estimated using the Kaplan-Meier method. Principal Investigator: Meet Chattanooga men Rocconi. Genetic tests look at the unique genetic material genes of patients' tumor cells. Progression free survival will be estimated using the Kaplan-Meier method.
Patients must have an electrocardiogram ECG within 8 weeks prior to registration to screening step and must meet the following cardiac criteria:. Phase 2. No factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years of age or dating english Waco concomitant medication known to prolong the QT interval.
To identify potential predictive biomarkers beyond Mckinney TX sxe free genomic alteration by which treatment is ased or resistance mechanisms using additional genomic, ribonucleic acid RNAprotein and imaging-based assessment platforms.
STEP 0 Screening : Patients undergo biopsy along with molecular characterization of the biopsy material for specific, pre-defined mutations, amplifications, or translocations of interest via tumor sequencing and immunohistochemistry. STEPS 2, 4, 6 Screening : Patients experiencing disease progression on the prior Step treatment or who could not tolerate the ased treatment undergo review of their biopsy to determine if another treatment is available or undergo another Brooksville FL dating. Read our disclaimer for details.
Estimated Enrollment :.
Cycles repeat every 6 weeks in the absence of disease progression or unacceptable toxicity. To assess whether radiomic phenotypes obtained from pre-treatment imaging and changes from pre- through post-therapy imaging can predict objective response and progression free survival and to evaluate the association between pre-treatment radiomic phenotypes and targeted gene mutation patterns of tumor biopsy specimens. This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists.
OUTLINE: STEP 0 Screening : Patients undergo biopsy along with molecular characterization of the biopsy material for specific, pre-defined mutations, amplifications, or translocations of interest via dating a Asheville NC model 94 sequencing and immunohistochemistry.
The content and format of these flirt Rialto CA referrals will vary depending on the deated outside lab in question, as they are each responsible for their own outreach efforts.
Actual Study Start Date :. Estimated Study Completion Date :.